American scientists successfully tested on animals “a pill from a hang-over”

American scientists have tested in mice a drug of enzymes that helps the liver decompose ethyl alcohol and its decomposition products. In drunken mice treated with an experimental drug, the level of alcohol in the blood rapidly decreased, and the concentration of dangerous its oxidation product – acetaldehyde, which causes the symptoms of a hangover – was very low.

American scientists successfully tested on animals "a pill from a hang-over"

A team led by Feng Yun Lu (Yunfeng Lu) from the University of California at Los Angeles developed and tested in mice a cure for a hangover – a cocktail of enzymes and liver targeted delivery system. The results of the experiment are encouraging; researchers expect to receive the first effective human medicine in the future to combat the consequences of alcohol use.

The head of the research group Yun Feng Lu himself – a great wine lover, and to create a cure for the hangover began not only from altruism – but also from it as well. Poisoning with alcohol and its metabolites is 8-10% of all calls to ambulance services around the world, besides – the cause of many diseases.

Effective withdrawal of alcohol from the body doctors can not yet; you have to rely on the natural “cleansing station” of the body – the liver, where alcohol under the action of the enzyme alcohol dehydrogenase is converted to acetaldehyde. This substance – the root of all hangover afflictions: it is much more toxic than alcohol itself, precisely because of his people are suffering from a headache, weakness, nausea and other symptoms of intoxication. The most excruciating hangover is when the alcohol got into the body too much, and the liver did not have the enzyme to decompose it. Eventually liver disposes and acetaldehyde – by the enzyme acetaldehyde dehydrogenase, which under the action of the toxin is converted to a relatively harmless acetic acid.

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Group Yun Feng Lu entered three enzymes – alcohol oxidase and catalase involved in the conversion of alcohol to acetaldehyde and aldehyde dehydrogenase in the nanocapsules of the previously approved for medical use of the material of the capsule and introduced into the bloodstream of laboratory mice drunk. “Cocktail” quickly found itself in the liver and accelerated the metabolism of alcohol; the concentration of alcohol in the blood of mice very quickly fell by as much as 45%, and the concentration of acetaldehyde remained very low. Mice from the group that received the antidote, faster than mice from the control group woke up after the “party”.

Now scientists continue experiments to make sure that nanocapsules with enzymes do not have dangerous side effects; During the year, researchers expect to begin experiments on humans.

The study is published in the journal Advanced Materials.


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